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Volume 25, Number 2, 2020

Evaluation of the target dose coverage of stereotactic body radiotherapy for lung cancer using helical tomotherapy: A dynamic phantom study

Masahide Saito, Hidekazu Suzuki, Naoki Sano, Kazunari Ashizawa, Kazuya Yoshizawa, Yuki Shibata, Koji Ueda, Takafumi Komiyama, Kan Marino, Shinichi Aoki, Ryo Saito, Yoshiyasu Maehata, Hiroshi Onishi

Summary:

Aim To evaluate the target dose coverage for lung stereotactic body radiotherapy (SBRT) using helical tomotherapy (HT) with the internal tumor volume (ITV) margin settings adjusted according to the degree of tumor motion. Background Lung SBRT with HT may cause a dosimetric error when the target motion is large. Materials and methods Two lung SBRT plans were created using a tomotherapy planning station. Using these original plans, five plans with different ITV margins (4.0–20.0 mm for superior-inferior [SI] dimension) were generated. To evaluate the effects of respiratory motion on HT, an original dynamic motion phantom was developed. The respiratory wave of a healthy volunteer was used for dynamic motion as the typical tumor respiratory motion. Five patterns of motion amplitude that corresponded to five ITV margin sizes and three breathing cycles of 7, 14, and 28 breaths per minute were used. We evaluated the target dose change between a static delivery and a dynamic delivery with each motion pattern. Results The target dose difference increased as the tumor size decreased and as the tumor motion increased. Although a target dose difference of <5 % was observed at ≤10 mm of tumor motion for each condition, a maximum difference of -9.94 % ± 7.10 % was observed in cases of small tumors with 20 mm of tumor motion under slow respiration. Conclusions Minimizing respiratory movement is recommended as much as possible for lung SBRT with HT, especially for cases involving small tumors.

Signature: Rep Pract Oncol Radiother, 2020; 25(2) : 200-205


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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2