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Volume 15, Number 5, 2010

Tracheal cancer: role of radiation therapy

Marcin Hetnał,  Alicja Alicja Kielaszek-Ćmiel, Magdalena Wolanin,
Stanisław Korzeniowski, Krzysztof Małecki,  Beata Sas-Korczyńska,  Piotr Brandys, Monika Chłosta,  Anna Kokoszka


Purpose: To assess the results of tracheal cancer patients treatment and factors influencing prognosis.
Material and Methods: Between 1962 and 2006, fifty patients diagnosed with tracheal cancer were treated at the Centre of Oncology in Krakow. The analysis focused on locoregional recurrence-free survival, disease free survival (DFS) and overall survival (OS). Survival rates, univariate and multivariate analyses of prognostic factors were performed using the Kaplan-Meier method, the log rank test and Cox's proportional hazard method, respectively.
For over 40 years, Patients were treated using different modalities: surgery followed by radiotherapy (6%), radiotherapy (78%), chemoradiotherapy (8%), symptomatic treatment (8%).
Results: The 5-year LRRFS was 18%, DFS was 15% and OS was 17%. Gender (favoured females) was the only prognostic factor for LRRFS. For OS, the independent prognostic factors were performance status (favoured Karnofsky higher than 80), stage and year of start of the treatment (later than 1988 vs. earlier - 5-year OS 20% vs. 12%). 5-year OS in the following (strongly differentiated over the time) treatment modalities were: surgery followed by radiotherapy (66%), radiotherapy (16%), chemoradiotherapy (0%), symptomatic
treatment (0%). Of 44 patients treated with radiotherapy symptomatic partial response was observed in 32 patients and follow-up imaging studies revealed complete response in 5 patients, partial response in 25, stable disease in 4 or progressive disease in 4.
Conclusions: Radical treatment in patients in early stage and good performance status seems to be correlated with improvement of survival.
However, despite the fact that results of treatment are poor, radiotherapy offers symptomatic

Signature: Rep Pract Oncol Radiother, 2010; 15(5) : 113-118

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